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Preliminary Characterization of the American Gut Population

If you have been following American Gut Project, you might be interested in the PDF we just released (see below) of a “top level” summary of the first ~1,000 people who gave it up for science.

Screen Shot 2013-09-17 at 3.51.14 AMWe have, as of September 5, 2013, completed sequencing and quality control of the gut bacteria from the first 1080 samples from 844 participants in the American Gut study. While we are working hard on priority #1 – providing your individual results back to you as soon as possible – we thought a quick look at some of the population level data would be interesting.

This document (CLICK HERE for PDF) gives a first look at results for the whole population. Your individual results (if your sample is among these first 1080 samples) will be available shortly.

 

 

7 Comments

  1. Jeff, are you in a position to comment (even preliminarily) on differences between paleo and lc paleo (if any)?

    Also, what the particular diets / circumstances where of the outliers mentioned (over 90% fermicutes and less than 1%)?

    • too early 2 tell. sample size is too small. we should have a few more thousand samples sequenced in the coming months and the paleo / lcPaleo sample size will hopefully increase – so stay tuned.

  2. Could you discuss a bit about the Fig 5 fecal graph? Why are you further to the left than ‘Pollan pre’? Could one get much further left than you?

    • Good Q. I eat lots of dietary fiber from a lot of sources. I also eat lots of cellulose – ie, the parts of the plants that many folks discard. So, my higher levels of Firmicutes is being driven by lots and lots of ruminococcus – that is, I look like grazing animals (eg, white rhino!). Pollan has tons and tons of Prevotella – which are part of the Bacteroidetes phylum. Note also, there was data years ago that indicated a high level of Firmicutes was predictive of obesity – that is, more Firmicutes, more junk in the trunk. This has not held up as more data comes in. Me for example, BMI of 25.

  3. Interesting… just got my results back… Unusual very sig spike in Actinobacteria compared to all groups :-) And some Staph as well… hmm .

    • Howard – Perfect timing. This young lady just posted her AmGut results and compared to mine–world of difference.

      We – similar diets
      She – lots of antibiotics
      Me – no antibiotics for 10+ years, and megadosing with resistant starch.

      My result showed I had 11X the number of bifidobacteria of anyone else–that is amazing when you think about it. All my other phyla/species were in line with a well-diversified gut microbiome. Laura’s showed very restricted growth, hardly any diversity at all.

      I’d like to see if ANYONE anywhere has more bifido than I do, resistant starch is a proven builder of friendly gut bugs.

      Have a look: http://www.ancestralizeme.com/2013/12/20/my-american-gut-results/

  4. would love to see gut results for normal vs. IBD people

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